Dr. Aubrey de Grey: One of the most important men in Longevity Escape Velocity

Aubrey De Grey is a researcher and author in the field of gerontology and the biology of aging. He is best known for his work as the Chief Science Officer and co-founder of the SENS Research Foundation, an organization dedicated to developing and promoting regenerative therapies to extend healthy human lifespan. De Grey holds a PhD in Biology from the University of Cambridge and is a recognized expert in the field of aging research. He is the author of several scientific papers and has given numerous lectures and presentations on the subject of aging and longevity. De Grey’s work has received widespread recognition and has been featured in numerous international media outlets, including The New York Times, Time Magazine, and CNN. He is a frequent speaker at conferences and events on aging research and has received numerous awards for his work, including the 2009 Hope Award for Research and the 2009 Vegan Society Peter Seth Freedom Prize.

Aubrey De Grey’s “Strategies for Engineered Negligible Senescence” (SENS) theory proposes that aging can be treated and reversed by repairing seven different types of molecular and cellular damage. These types of damage are:

1. Cell loss and atrophy — caused by the loss of cells in tissues, which can result in the decline of organ function. De Grey hopes to mitigate this damage by developing regenerative therapies that promote the growth of new cells in tissues.
2. Nuclear mutations and epimutations — caused by mutations or changes to the genetic material in cells, which can result in the development of age-related diseases. De Grey hopes to mitigate this damage by developing gene therapies that can correct mutations or changes in the genetic material.
3. Mitochondrial mutations — caused by mutations in the cellular powerhouses called mitochondria, which can result in a decline in cellular energy and increased oxidative damage. De Grey hopes to mitigate this damage by developing therapies that can replace damaged mitochondria with healthy ones.
4. Junk outside cells — caused by the buildup of harmful waste products outside cells, which can result in inflammation and the accumulation of harmful proteins. De Grey hopes to mitigate this damage by developing therapies that can remove these waste products from the body.
5. Junk inside cells — caused by the buildup of harmful waste products inside cells, which can result in the loss of function and death of cells. De Grey hopes to mitigate this damage by developing therapies that can break down these waste products and remove them from cells.
6. Cell senescence — caused by cells ceasing to divide and becoming senescent, which can result in inflammation and the release of harmful signals. De Grey hopes to mitigate this damage by developing therapies that can remove senescent cells from the body.
7. Extracellular matrix stiffening — caused by the stiffening of the extracellular matrix, which can result in the decline of organ function and the development of age-related diseases. De Grey hopes to mitigate this damage by developing therapies that can restore the elasticity and flexibility of the extracellular matrix.

De Grey believes that by addressing these seven forms of molecular and cellular damage, it will be possible to extend healthy lifespan and delay or prevent age-related diseases.

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Some of Aubrey de Grey’s published books:

[embed][Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime [de Grey, Aubrey, Rae…amzn.to](https://amzn.to/3x9HwmQ)

[embed]Advancing Conversations: Aubrey De Grey - Advocate For An Indefinite Human Lifespan Advancing Conversations is a line of interview books documenting conversations with artists, authors, philosophers…amzn.to