How Cells Adapt to Changes in Oxygen Availability
The coordinated roles of HIF, Nrf2, and NF‑κB
How Cells Adapt to Changes in Oxygen Availability
The coordinated roles of HIF, Nrf2, and NF‑κB
Oxygen supports efficient metabolism, but its availability must be tightly controlled. Cells rely on interconnected transcriptional responses to adapt to both scarcity and excess.
Original article: Need (more than) two to Tango: Multiple tools to adapt to changes in oxygen availability, 10.1002/biof.1419, https://iubmb.onlinelibrary.wiley.com/doi/10.1002/biof.1419
Q&A Why do cells need multiple oxygen‑responsive pathways? Because even small oxygen fluctuations can be stressful, requiring distinct yet integrated transcriptional responses.
What role does NF‑κB play? It acts as a pivotal determinant that integrates signals from HIF and Nrf2.
Key results • Oxygen homeostasis depends on coordinated transcription factors. • HIF and Nrf2 address different oxygen extremes. • NF‑κB links and modulates these responses.
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