Xianjue Bio: Vascularization + Immune Microenvironment + AI Closed Loop

The Next-Generation Organoid Technology Paradigm

Traditional organoid models lack perfusable vasculature, functional immune systems, and efficient data analysis.

Xianjue Bio (Suzhou BioXGEN) has built China’s only integrated platform:

Vascularization + Immune Microenvironment + AI Closed Loop

Vascularized Microphysiological Technology

· Integrates 3D bioprinting and microfluidics to build perfusable functional microvascular networks.

· Uses proprietary peptide and extracellular matrix bionic hydrogel to promote vascular self-assembly.

· Vascular networks remain stable for more than 21 days.

· Recapitulates tumor–vascular crosstalk consistent with clinical pathology.

Immune Microenvironment Reconstruction

· Introduces patient-derived immune cells to simulate real tumor–immune interactions.

· Recapitulates lung cancer heterogeneity: vascularized clusters vs. non-vascularized spheres.

· Enables direct observation of PBMC infiltration and tumor cell apoptosis in anti–PD-1 treatment.

· Improves accuracy of immunotherapy drug screening.

AI-Powered Intelligent Analysis

· Multi-modal imaging: brightfield, fluorescence, digital confocal.

· 4D dynamic capture: temporal continuous observation + spatial 3D scanning.

· AI automatically quantifies cell number, area, morphology, circularity, etc.

· Supports 2D/3D reconstruction and automatic report generation.

· Forms a closed loop: Culture → Imaging → Analysis → Regulation.

Integrated Applications

· Hospitals: Personalized drug sensitivity testing.

· Research Institutes: Custom disease models.

· Pharmaceutical Companies: Preclinical efficacy/toxicity testing, reducing animal studies.

Xianjue Bio is a national high-tech enterprise with a full-chain system: biomaterials, chips, instruments, software, and services.