#bioinformatics

Biotech, Biomed, Bioinfo… Wait, What’s the Difference?

Biotechnology is an alternative career option for almost every NEET dropper or aspirant. But do you all really know about it?!?

Tech conference experience + Genomics tech stack

I attended my first technical conference in August 2026. It was PyConAU26, and I was lucky that it was in my city and I was aware of it. I…

Single-Cell RNA-seq for Beginners #1: From FASTQ to an Expression Matrix with Cell Ranger

A practical, reproducible walkthrough for 10x Genomics data — from read structure and public-data download to cellranger count, QC, and the…

Second Experiment: Can a Local 27B Vision-Language Model Build and Verify a Scientific Heatmap?

Abstract

SNP Liftover Explained: Why Variants Don’t Match After Converting GRCh37 to GRCh38

A practical guide to genome coordinate conversion, REF/ALT harmonization, 0-based vs. 1-based coordinates, and post-liftover quality…

Maya Proteinlerinde Konum Tahmini: Bir Random Forest Modelini Gerçekten Sorgulamak

Giriş

Understanding Alphafold 1, all the essentials for computer scientists

Recently, Google DeepMind reportedly decided to dismantle the AlphaFold team. I have long admired the AlphaFold series — AlphaFold 1…

What Is Computational Protein Design? A Beginner’s Introduction

Proteins are among the most versatile molecules in biology. They transport oxygen, digest food, transmit signals between cells, recognize…

Bioinformatics Career in 2026: Jobs, Skills, Salary & Future Scope

The life sciences industry is becoming increasingly connected with technology, data and artificial intelligence. This change is creating…

Decoding the human immune system: A game developer’s perspective

Part 1: A brief overview of how immune system works in terms of computer science and game development concepts

Why I Started Building AI for Biomedical Discovery

A personal journey from bioinformatics analysis to discovery intelligence.

# The biotech laptop jobs nobody in india talks about

## While everyone’s stuck on lecturer, phd, or government exams, an entire industry is booming without them noticing

Biopython: Protein shapes and Phylogenetic trees — Part 3

So far everything in this series has been flat. Sequences are just letters in a row, and even alignment and BLAST are really about…

Bioinformatics Pipelines for Microbiome Analysis with Python and QIIME 2

The Biopython basics I use in almost every script — Part 01

Most of my early bioinformatics code did things that Biopython already does in one line. I just didn’t know it yet. I was splitting strings…

From Signal to Drug 01: Visualizing AI-Based Target Discovery with Geneformer

AI-driven drug discovery is often described as a continuous pipeline. In practice, the relevant information is usually scattered across…

Does Pathology-Specific Pretraining Beat ImageNet?

Pitting a pathology foundation model (Phikon-v2) against ImageNet-pretrained CNNs for nine-class tissue classification on H&E-stained…

From FASTQ to PLINK: An End-to-End NGS Pipeline on Apple Silicon

Building, validating, and troubleshooting a complete germline variant calling workflow on Apple Silicon

Contributing to Open-Source Bioinformatics: Our Experience at the nf-core Hackathon from Medellín

Written by Andres Florian and Daniel Sabogal

NGS Data Analysis: A Step-by-Step Guide from FASTQ Files to Biological Insights

Learn how NGS data analysis transform

From Proteins to Pipelines: How Open-Source Nextflow Tools Are Accelerating Drug Discovery

Written by Jelena Pejovic, Senior Bioinformatic Engineer and Jorge Moura Sampaio, Bioengineering Lead

How NMR Metabolites is new ERA of Thailand HEALTHCARE?

ปัจจุบันแพลตฟอร์มเชิงพาณิชย์อย่าง Nightingale Health สามารถรายงาน biomarkers ได้ประมาณ 250 ตัว ซึ่งให้ข้อมูลละเอียดมาก…

AI Democratizes the Appearance of Expertise. In Genomics, That’s a Problem.

There’s a growing trend in genomics: everything is suddenly “AI-powered.”

Your First Dry Lab Setup: Python, RDKit, and Google Colab

A Chemist’s Guide to Cheminformatics • Article 3 of 11

Bioinformatics Software Development for Clinical Genomics Platforms

Building a bioinformatics pipeline for research is one thing. Building one that reliably processes thousands of patient samples in a…

Hackathons, Bioinformatics, and being in Australia

The first hackathon I ever signed up for was in 2019. I thought I’d written about that particular experience, but it seems I only wrote…

The Beginner’s Guide to Consensus Docking: Why One Docking Program Isn’t Enough Anymore

When predicting how a potential drug binds to its target, should researchers trust just one computational tool? Increasingly, the answer is…

Forensic Genomics of Clostridium perfringens: Whole Genome Sequencing for Foodborne Outbreak…

Author: Maisyarah Dyah Utami Institution: Universitas Terbuka Bioinfomatics Beginner Bootcamp: Whole Genome Sequencing by INBIO

From Raw Reads to Microbial Insights: My Journey Analyzing the Breast Tissue Microbiome with QIIME2

Project Summary

How Proteins Fold and Why AlphaFold Changed Everything

In 1972, a biochemist named Christian Anfinsen won the Nobel Prize for proving that a protein’s shape is entirely determined by its…

In Praise of “I Don’t Know”

Why the most valuable thing a model can tell you, whether it reads genomes or writes sentences, is the limit of its own confidence

Understanding Pseudobulking in Single Cell: Why 10,000 cells is sometimes just N = 6

A few months ago, my students were analyzing single-cell data comparing non-alcoholic steatohepatitis against a normal liver. The reasoning…

What Your Spatial Transcriptomics Analysis Misses, and How Topology Finds It

Moran’s I is the standard tool for spatial gene expression. It has a specific, well-defined blind spot. Here is how persistent homology…

Essential Calculations in Molecular Biology: A Beginner-Friendly Guide (Continued)

In continuation of our previous discussion on basic DNA calculations, we now move forward to explore some more important concepts in…

How Computers See Molecules: SMILES, InChI, and Molecular Representations

A Chemist’s Guide to Cheminformatics • Article 2 of 11

The Long Tail of Slow Bioinformatics Software, and an Agent Built to Fix It

Many bioinformatics functions become everyday infrastructure long before anyone has time to make them fast.

Why Cancer Learns to Ignore the Drug That’s Killing It

Continuous chemo suppressed disease longest and created the most complete resistance. A simulation of why dosing schedule matters

Looking Through DeepVariant’s Eyes- But In Your Browser

What happens when you take a CNN trained on ImageNet and point it at genomes? It works. Here’s a browser tool where you can watch the whole…

How to Run ssGSEA Immune Infiltration Analysis with an AI Agent Skill (2026)

Immune infiltration analysis is a commonly used approach for exploring immune-related patterns in bulk RNA-seq datasets. Researchers often…

How to Run ssGSEA Immune Infiltration Analysis with an AI Agent Skill (2026)

Immune infiltration analysis is a commonly used approach for exploring immune-related patterns in bulk RNA-seq datasets. Researchers often…

Beyond Clusters and Plots: Building CellFateBench, a Benchmark for Single-Cell Genomics Reasoning

How CellFateBench turns single-cell workflows into public tasks, hidden answer keys, oracle outputs, scoring, calibration, Docker…

ESM: When the Bitter Lesson Reaches Biology

How Language Modeling Materializes a World Model of Protein Biology

Beyond Topology: Combining Biological Features with Network Structure

What happens when we add biological node features and compare against topology-only approaches?

Text2Prot Search: Bridging Text, Sequence, and Structure with Multimodal AI

A new era where you can understand protein function just by talking to it is truly coming.

A Brief Tale of AstroVirus

Another zoonotic virus with pandemic potential?

How AI Agents Run Immune Pathway Analysis (2026)

Originally published at https://www.aipoch.com.

DNA Is Now a Technology. Here’s Why That Changes Everything

Every single thing about you and me- the colour of your eyes, how your body fights off a cold, even your risk of certain diseases is…

The Molecular Logic of Life: A Modern Perspective on the Central Dogma

An exploration of Andrei Cristian Grădinaru’s reinterpretation of the Central Dogma and its implications for modern molecular biology.

FROM BENCH TO BYTES

A Chemist’s Guide to Cheminformatics • Article 1 of 11

What Are the Current Challenges in Cognitive Genomics?

Abstract