#protac

Cracking the PROTAC Permeability Barrier: CD36-Mediated Endocytosis as a Potential Breakthrough

I Background: PROTACs — great potential, real challenges

AI Approaches in PROTACs: The New Frontier in Targeted Protein Degradation

In continuation of our previous blog series on PROTAC Design, Parts 1 and 2 of this series set the stage: Part…

From AR Antagonism to Dual Degradation: A PSMA-Targeted Nano-PROTAC for Drug-Resistant Prostate…

https://www.nature.com/articles/s41392-025-02444-z

From ‘Undruggable’ to Ubiquitous: Pan-KRAS Inhibition and Targeted KRAS Degradation for RAS-Driven…

https://www.cell.com/cancer-cell/fulltext/S1535-6108(25)00310-1

CBPD-409: A New Class of Epigenetic Degrader Redefining AR-Driven Cancer Therapy

https://www.nature.com/articles/s41588-025-02336-6

Molecular Glues & PROTACs Meet Their Match: Inside the Humanized CRBN Mouse Model

A Defining Moment for Targeted Protein Degradation

Potential of Arvinas’ PROTAC® AR Degraders Reinforced by

Potential of Arvinas’ PROTAC® AR Degraders Reinforced by

PROteolysis Targeting Chimera (PROTAC) Market, Global Outlook and Forecast 2023–2032

The global PROteolysis Targeting Chimera (PROTAC) market was valued at US$ million in 2022 and is projected to reach US$ million by 2029…

PROTAC — o2h discovery’s biology expertise

🧬Our biology evaluation suite aims to help you estimate ternary complex formation and targeted protein degradation. Our team at o2h…

Natural Products in Protein Degradation: Past, Present, and Future

Protein degradation, whether as a PROTAC (proteolysis targeting chimera) or a molecular glue, is an emerging new modality of therapeutic…